Spending any time on twitting is primarily a waste of time…
…for YOU as a content provider anyway.
Having a bunch of followers that are interested in your CONTENT can, one the other hand, only be good. There is a site called www.twitterfeed.com where you can set up RSS feeds and automatically add to your twitter account.
This is a free service – although you can and should donate if you find it works for you.
Really simple to setup – and after that – hands free. Just add your RSS feed URLs!
If you have more than one feed you can even prefix each one with a describing keyword.
I am trying this out for my twitter account at: www.twitter.com/digital_design – check it out and let me know what you think 
For this test I am collecting feeds from all my sites (SBI and non SBI).
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Yes searching for people within Twitter using your niche keywords gives you a group of followers that are highly targeted and very interested in your content.